UMRS 1349 at Sorbonne Paris Nord University

Publications

Selected Publications

2026

Lipoprotein Metabolism in Hematological Malignancies: A Role in Shaping the Tumor Cell Microenvironment
Lipoprotein Metabolism in Hematological Malignancies: A Role in Shaping the Tumor Cell Microenvironment?
Manal Sellam, Mélanie Lambert, Nadine Varin-Blank, Kevin Saitoski
Metabolites  ·  20 Feb 2026  ·  doi:10.3390/metabo16020145
test
new0

2025

Clinical and transcriptomic characterization of patients with chronic lymphocytic leukemia harboring t 14;19 : an ERIC study
Clinical and transcriptomic characterization of patients with chronic lymphocytic leukemia harboring t(14;19): an ERIC study
Andrea Visentin, Enrico Gaffo, Moritz Fürstenau, Kerry A. Rogers, Baliakas Panagiotis, …, Antonio Cuneo, Paolo Ghia, Kostas Stamatopoulos, Livio Trentin, Stefania Bortoluzzi
Leukemia  ·  19 Sep 2025  ·  doi:10.1038/s41375-025-02755-8
test
new12-2
Circular RNA signature of aggressive CLL with t 14;19 q32;q13 . An ERIC study
Circular RNA signature of aggressive CLL with t(14;19)(q32;q13). An ERIC study
Eleonora Roncaglia, Enrico Gaffo, Giulia Calabretto, Moritz Fürstenau, Kerry A. Rogers, …, Paolo Ghia, Kostas Stamatopoulos, Livio Trentin, Andrea Visentin, Stefania Bortoluzzi
Journal of Hematology & Oncology  ·  22 Jul 2025  ·  doi:10.1186/s13045-025-01725-y
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new11
The Critical Role of Adipocytes in Leukemia
The Critical Role of Adipocytes in Leukemia
Romane Higos, Kevin Saitoski, Mathieu Hautefeuille, Geneviève Marcelin, Karine Clément, Nadine Varin-Blank, Christophe Breton, Simon Lecoutre, Mélanie Lambert
Biology  ·  28 May 2025  ·  doi:10.3390/biology14060624
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new7
ATM aberrations in chronic lymphocytic leukemia: del 11q rather than ATM mutations is an adverse-prognostic biomarker
ATM aberrations in chronic lymphocytic leukemia: del(11q) rather than ATM mutations is an adverse-prognostic biomarker
Birna Thorvaldsdottir, Larry Mansouri, Lesley-Ann Sutton, Ferran Nadeu, Manja Meggendorfer, …, Elias Campo, Jonathan C. Strefford, Paolo Ghia, Kostas Stamatopoulos, Richard Rosenquist
Leukemia  ·  24 Apr 2025  ·  doi:10.1038/s41375-025-02615-5
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new12-1
Dissection of single-cell landscapes for the development of chimeric antigen receptor T cells in Hodgkin lymphoma
Dissection of single-cell landscapes for the development of chimeric antigen receptor T cells in Hodgkin lymphoma
Adrian Gottschlich, Ruth Grünmeier, Gordon Victor Hoffmann, Sayantan Nandi, Vladyslav Kavaka, …, Andreas Rosenwald, Michael von Bergwelt-Baildon, Paul J. Bröckelmann, Stefan Endres, Sebastian Kobold
Blood  ·  03 Apr 2025  ·  doi:10.1182/blood.2023022197
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new6
Targeted therapies overcome the poor prognosis of stereotyped Subset 2 chronic lymphocytic leukemia : a real-world multicentric study
Targeted therapies overcome the poor prognosis of stereotyped Subset#2 chronic lymphocytic leukemia : a real-world multicentric study
Lucile Bussot, Stéphanie Poulain, Morgane Nudel Ortmans, Frédéric Davi, Damien Roos-Weil, …, Céline Lechat, Caroline Dartigeas, Émilie Montaut, Lysiane Molina, Sylvain Carras
Leukemia  ·  01 Apr 2025  ·  doi:10.1038/s41375-025-02555-0
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new1
Understanding kidney involvement in mycosis fungoides: T-cell clonality as a guide for targeted therapy a case report and literature review
Understanding kidney involvement in mycosis fungoides: T-cell clonality as a guide for targeted therapy – a case report and literature review
Jelena Filipović, Eve Maubec, Clelia Previtali, Milica Višić, Beatrice Villette, Gregory Lazarian, Remi Letestu, Joel Cucherousset, Michael Soussan, Antoine Martin
BMC Nephrology  ·  24 Mar 2025  ·  doi:10.1186/s12882-025-04014-5
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new3
Bortezomib, Rituximab and Dexamethasone Regimen BDR in Waldenström Macroglobulinaemia: A Retrospective Real World Analysis
Bortezomib, Rituximab and Dexamethasone Regimen (BDR) in Waldenström Macroglobulinaemia: A Retrospective Real‐World Analysis
Thomas Hueso, Grégory Lazarian, Paul Chauvet, Adrien Chauchet, Ramy Rahmé, …, Claude Gardin, Fanny Baran‐Marszak, Eric Durot, Pierre Morel, Thorsten Braun
eJHaem  ·  19 Mar 2025  ·  doi:10.1002/jha2.70019
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new8
scp i TP53 i scp Mutations Detected by scp NGS scp Are a Major Clinical Risk Factor for Stratifying Mantle Cell Lymphoma
TP53 Mutations Detected by NGS Are a Major Clinical Risk Factor for Stratifying Mantle Cell Lymphoma
Grégory Lazarian, Lotfi Chemali, Merieme Bensalah, Carla Zindel, Valérie Lefebvre, …, Elsa Maitre, Florence Cymbalista, Vincent Levy, Thierry Soussi, Fanny Baran‐Marszak
American Journal of Hematology  ·  06 Mar 2025  ·  doi:10.1002/ajh.27650
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new9
Multiplex digital PCR enables sensitive detection of resistance to BTK inhibitors
Multiplex digital PCR enables sensitive detection of resistance to BTK inhibitors
Manon Garcia, Carolyne Croizier, Grégory Lazarian, Anne Quinquenel, Thomas Tassin, …, Jacques-Olivier Bay, Marc G. Berger, Andréi Tchirkov, Lauren Véronèse, Romain Guièze
Annals of Hematology  ·  24 Jan 2025  ·  doi:10.1007/s00277-025-06200-9
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new4
Inflammatory Waldenström macroglobulinemia is associated with clonal hematopoiesis: a multicentric cohort
Inflammatory Waldenström macroglobulinemia is associated with clonal hematopoiesis: a multicentric cohort
Pierre-Edouard Debureaux, Stéphanie Poulain, Stéphanie Harel, Marie Passet, Marie Templé, …, Olivier Kosmider, Emmanuelle Clappier, Marion Espéli, Karl Balabanian, Bertrand Arnulf
Blood  ·  23 Jan 2025  ·  doi:10.1182/blood.2024025738
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new2
Detection of clinically relevant variants in the i TP53 i gene below 10 allelic frequency: A multicenter study by ERIC, the European Research Initiative on CLL
Detection of clinically relevant variants in the TP53 gene below 10% allelic frequency: A multicenter study by ERIC, the European Research Initiative on CLL
Sarka Pavlova, Jitka Malcikova, Lenka Radova, Silvia Bonfiglio, Jack B. Cowland, …, Richard Rosenquist, Carsten U. Niemann, Kostas Stamatopoulos, Paolo Ghia, Sarka Pospisilova
HemaSphere  ·  01 Jan 2025  ·  doi:10.1002/hem3.70065
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new10

2024

The survival grip how cell adhesion promotes tumor maintenance within the microenvironment
The survival grip–how cell adhesion promotes tumor maintenance within the microenvironment
Laura Gardano, Jordan Ferreira, Christine Le Roy, Dominique Ledoux, Nadine Varin‐Blank
FEBS Letters  ·  20 Dec 2024  ·  doi:10.1002/1873-3468.15074
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new5
The contribution of high-throughput sequencing in malignant hematological disorders .
[The contribution of high-throughput sequencing in malignant hematological disorders].
Pierre Sujobert, Anne-Sophie Alary, Fanny Baran-Marszak, Jean-Michel Cayuela, Pascale Flandrin, Damien Luque Paz, Olivier Kosminder
La Revue du praticien  ·  01 Dec 2024  ·  PMID:40546206
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new16
Cancer associated variant enrichment CAVE, a gene agnostic approach to identify low burden variants in chronic lymphocytic leukemia
Cancer associated variant enrichment CAVE, a gene agnostic approach to identify low burden variants in chronic lymphocytic leukemia
Adar Yaacov, Gregory Lazarian, Tatjana Pandzic, Simone Weström, Panagiotis Baliakas, …, Valérie Lefebvre, Florence Cymbalista, Fanny Baran-Marszak, Shai Rosenberg, Thierry Soussi
Scientific Reports  ·  20 Sep 2024  ·  doi:10.1038/s41598-024-73027-1
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new17
Blinatumomab after R-CHOP bridging therapy for patients with Richter transformation: a phase 2 multicentre trial
Blinatumomab after R-CHOP bridging therapy for patients with Richter transformation: a phase 2 multicentre trial
Romain Guièze, Loïc Ysebaert, Damien Roos-Weil, Luc-Mathieu Fornecker, Emmanuelle Ferrant, …, Marie de Antonio, Camille Laurent, Olivier Tournilhac, Bruno Pereira, Pierre Feugier
Nature Communications  ·  09 Aug 2024  ·  doi:10.1038/s41467-024-51264-2
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new14
Clinical and biological characterization of involvement of nasal associated lymphoid tissues in chronic lymphocytic leukemia
Clinical and biological characterization of involvement of nasal‐associated lymphoid tissues in chronic lymphocytic leukemia
Thimali Ranaweera Arachchige, Catherine Mendiburu, Antoine Martin, Carole Fleury, Elisabetta Dondi, Rémi Letestu, Virginie Eclache, Fanny Baran‐Marszak, Florence Cymbalista, Gregory Lazarian
American Journal of Hematology  ·  10 May 2024  ·  doi:10.1002/ajh.27357
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test2
Editorial: Tumor microenvironment and hematological malignancies: new evidences and new questions
Editorial: Tumor microenvironment and hematological malignancies: new evidences and new questions
Stefania Fiorcari, Paolo Strati, Elisabetta Dondi
Frontiers in Immunology  ·  16 Apr 2024  ·  doi:10.3389/fimmu.2024.1407981
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new13

2023

Identification of the Axis β-Catenin BTK in the Dynamic Adhesion of Chronic Lymphocytic Leukemia Cells to Their Microenvironment
Identification of the Axis β-Catenin–BTK in the Dynamic Adhesion of Chronic Lymphocytic Leukemia Cells to Their Microenvironment
Imane Mihoub, Tareck Rharass, Souhaïl Ouriemmi, Antonin Oudar, Laure Aubard, …, Fanny Baran-Marszak, Nadine Varin-Blank, Dominique Ledoux, Christine Le Roy, Laura Gardano
International Journal of Molecular Sciences  ·  18 Dec 2023  ·  DOI:10.3390/ijms242417623
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new22
Inhibition of a new AXL isoform, AXL3, induces apoptosis of mantle cell lymphoma cells
Inhibition of a new AXL isoform, AXL3, induces apoptosis of mantle cell lymphoma cells
Pascal Gelebart, May Eriksen Gjerstad, Susanne Benjaminsen, Jianhua Han, Ida Karlsen, …, Mihaela Popa, Lars Helgeland, Bela Papp, Fanny Baran-Marszak, Emmet McCormack
Blood  ·  26 Oct 2023  ·  doi:10.1182/blood.2022015581
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new19
Inflammation is predictive of outcome in Waldenström macroglobulinemia treated by Bruton tyrosine kinase inhibitors: a multicentric real-life study
Inflammation is predictive of outcome in Waldenström macroglobulinemia treated by Bruton tyrosine kinase inhibitors: a multicentric real-life study
Pierre-Edouard Debureaux, Nathalie Forgeard, Dikelele Elessa, Stéphanie Harel, Laurent Frenzel, …, Olivier Hermine, Damien Roos-Weil, Marion Espéli, Karl Balabanian, Bertrand Arnulf
Haematologica  ·  16 Aug 2023  ·  doi:10.3324/haematol.2023.283141
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new12-3
Immuno-regulatory malignant B cells contribute to Chronic Lymphocytic Leukemia progression
Immuno-regulatory malignant B cells contribute to Chronic Lymphocytic Leukemia progression
Arsène Mékinian, Anne Quinquenel, Koceïla Ait Belkacem, Feriel Kanoun, Elisabetta Dondi, …, Rémi Letestu, Florence Ajchenbaum-Cymbalista, Vincent Lévy, Nadine Varin-Blank, Christine Le Roy
Cancer Gene Therapy  ·  28 Mar 2023  ·  DOI:10.1038/s41417-023-00602-5
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new21
Molecular characterization of Richter syndrome identifies de novo diffuse large B-cell lymphomas with poor prognosis
Molecular characterization of Richter syndrome identifies de novo diffuse large B-cell lymphomas with poor prognosis
Julien Broséus, Sébastien Hergalant, Julia Vogt, Eugen Tausch, Markus Kreuz, …, José Ignacio Martin-Subero, Florence Cymbalista, Pierre Feugier, Reiner Siebert, Stephan Stilgenbauer
Nature Communications  ·  19 Jan 2023  ·  doi:10.1038/s41467-022-34642-6
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new18

2022

The strange case of nurse cells: Dr. Jekyll or Mr. Hyde
The strange case of nurse cells: Dr. Jekyll or Mr. Hyde?
Journal of Cellular and Molecular Immunology  ·  31 Dec 2022  ·  DOI:10.46439/immunol.1.011
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new24
Different prognostic impact of recurrent gene mutations in chronic lymphocytic leukemia depending on IGHV gene somatic hypermutation status: a study by ERIC in HARMONY
Different prognostic impact of recurrent gene mutations in chronic lymphocytic leukemia depending on IGHV gene somatic hypermutation status: a study by ERIC in HARMONY
Larry Mansouri, Birna Thorvaldsdottir, Lesley-Ann Sutton, Georgios Karakatsoulis, Manja Meggendorfer, …, Elias Campo, Jonathan C. Strefford, Paolo Ghia, Kostas Stamatopoulos, Richard Rosenquist
Leukemia  ·  24 Dec 2022  ·  DOI:10.1038/s41375-022-01802-y
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new20
Insulin-regulated aminopeptidase contributes to setting the intensity of FcR-mediated inflammation
Insulin-regulated aminopeptidase contributes to setting the intensity of FcR-mediated inflammation
Manuela Bratti, Shamila Vibhushan, Cyril Longé, Despoina Koumantou, Gaël Ménasché, Marc Benhamou, Nadine Varin-Blank, Ulrich Blank, Loredana Saveanu, Sanae Ben Mkaddem
Frontiers in Immunology  ·  27 Oct 2022  ·  DOI:10.3389/fimmu.2022.1029759
test
new23
Nurselike cells sequester B cells in disorganized lymph nodes in chronic lymphocytic leukemia via alternative production of CCL21
Nurselike cells sequester B cells in disorganized lymph nodes in chronic lymphocytic leukemia via alternative production of CCL21
Rim Zaaboub, Lene Vimeux, Vincent Contremoulins, Florence Cymbalista, Vincent Lévy, Emmanuel Donnadieu, Nadine Varin-Blank, Antoine Martin, Elisabetta Dondi
Blood Advances  ·  12 Aug 2022  ·  DOI:10.1182/bloodadvances.2021006169
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new29
Dihydroorotate dehydrogenase inhibition acts synergistically with tyrosine kinase inhibitors to induce apoptosis of mantle cell lymphoma cells
Dihydroorotate dehydrogenase inhibition acts synergistically with tyrosine kinase inhibitors to induce apoptosis of mantle cell lymphoma cells
May Eriksen‐Gjerstad, Ida Tveit Karlsen, Zinayida Fandalyuk, Susanne Benjaminsen, Fanny Baran‐Marszak, …, Frederick Locke, Marcus Ladds, Andrés Pastor‐Fernández, Pascal Gelebart, Emmet Mc Cormack
eJHaem  ·  15 May 2022  ·  DOI:10.1002/jha2.434
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new25
Impact of Low-Burden TP53 Mutations in the Management of CLL
Impact of Low-Burden TP53 Mutations in the Management of CLL
Gregory Lazarian, Florence Cymbalista, Fanny Baran-Marszak
Frontiers in Oncology  ·  08 Feb 2022  ·  DOI:10.3389/fonc.2022.841630
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new27
scp TP53 scp mutations at codon 234 are associated with chlorambucil treatment in chronic lymphocytic leukemia
TP53 mutations at codon 234 are associated with chlorambucil treatment in chronic lymphocytic leukemia
Grégory Lazarian, Floriane Theves, Myriam Hormi, Rémi Letestu, Virginie Eclache, …, Samia Imache, Valérie Lefebvre, Florence Cymbalista, Fanny Baran‐Marszak, Thierry Soussi
American Journal of Hematology  ·  01 Feb 2022  ·  DOI:10.1002/ajh.26479
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new28
Relapse of acquired von Willebrand syndrome in a patient non-compliant with Crohn s disease
Relapse of acquired von Willebrand syndrome in a patient non-compliant with Crohn's disease
Myriam Hormi, Melchior Le Méné, Céline Comparon, Imededdine El Kout, Fanny Baran-Marszak, Nathalie Itzhar-Baikian, Virginie Siguret, Robin Dhote
Annales de Biologie Clinique  ·  01 Feb 2022  ·  DOI:10.1684/abc.2021.1692
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new26

More

2023

Identification of the Axis β-Catenin BTK in the Dynamic Adhesion of Chronic Lymphocytic Leukemia Cells to Their Microenvironment
Identification of the Axis β-Catenin–BTK in the Dynamic Adhesion of Chronic Lymphocytic Leukemia Cells to Their Microenvironment
Imane Mihoub, Tareck Rharass, Souhaïl Ouriemmi, Antonin Oudar, Laure Aubard, …, Fanny Baran-Marszak, Nadine Varin-Blank, Dominique Ledoux, Christine Le Roy, Laura Gardano
International Journal of Molecular Sciences  ·  18 Dec 2023  ·  doi:10.3390/ijms242417623
test
test3
Immuno-regulatory malignant B cells contribute to Chronic Lymphocytic Leukemia progression
Immuno-regulatory malignant B cells contribute to Chronic Lymphocytic Leukemia progression
Arsène Mékinian, Anne Quinquenel, Koceïla Ait Belkacem, Feriel Kanoun, Elisabetta Dondi, …, Rémi Letestu, Florence Ajchenbaum-Cymbalista, Vincent Lévy, Nadine Varin-Blank, Christine Le Roy
Cancer Gene Therapy  ·  28 Mar 2023  ·  doi:10.1038/s41417-023-00602-5
test
test4

2022

Insulin-regulated aminopeptidase contributes to setting the intensity of FcR-mediated inflammation
Insulin-regulated aminopeptidase contributes to setting the intensity of FcR-mediated inflammation
Manuela Bratti, Shamila Vibhushan, Cyril Longé, Despoina Koumantou, Gaël Ménasché, Marc Benhamou, Nadine Varin-Blank, Ulrich Blank, Loredana Saveanu, Sanae Ben Mkaddem
Frontiers in Immunology  ·  27 Oct 2022  ·  doi:10.3389/fimmu.2022.1029759
Nurselike cells sequester B cells in disorganized lymph nodes in chronic lymphocytic leukemia via alternative production of CCL21
Nurselike cells sequester B cells in disorganized lymph nodes in chronic lymphocytic leukemia via alternative production of CCL21
Rim Zaaboub, Lene Vimeux, Vincent Contremoulins, Florence Cymbalista, Vincent Lévy, Emmanuel Donnadieu, Nadine Varin-Blank, Antoine Martin, Elisabetta Dondi
Blood Advances  ·  12 Aug 2022  ·  doi:10.1182/bloodadvances.2021006169
test
test5
Impact of Low-Burden TP53 Mutations in the Management of CLL
Impact of Low-Burden TP53 Mutations in the Management of CLL
Gregory Lazarian, Florence Cymbalista, Fanny Baran-Marszak
Frontiers in Oncology  ·  08 Feb 2022  ·  doi:10.3389/fonc.2022.841630
test6

2021

Regulatory interplay between Vav1, Syk and β-catenin occurs in lung cancer cells
Regulatory interplay between Vav1, Syk and β-catenin occurs in lung cancer cells
Rofia Boudria, Vanessa Laurienté, Antonin Oudar, Souleymane Harouna-Rachidi, Elisabetta Dondi, Christine Le Roy, Laura Gardano, Nadine Varin-Blank, Lionel Guittat
Cellular Signalling  ·  01 Oct 2021  ·  doi:10.1016/j.cellsig.2021.110079
test8
A hotspot mutation in transcription factor IKZF3 drives B cell neoplasia via transcriptional dysregulation
A hotspot mutation in transcription factor IKZF3 drives B cell neoplasia via transcriptional dysregulation
Gregory Lazarian, Shanye Yin, Elisa ten Hacken, Tomasz Sewastianik, Mohamed Uduman, …, Donna S. Neuberg, Fanny Baran-Marszak, Florence Cymbalista, Ruben D. Carrasco, Catherine J. Wu
Cancer Cell  ·  01 Mar 2021  ·  doi:10.1016/j.ccell.2021.02.003
test7

2020

Skewed peripheral B- and T-cell compartments in patients with ANCA-associated vasculitis
Skewed peripheral B- and T-cell compartments in patients with ANCA-associated vasculitis
Jonathan London, Nicolas Dumoitier, Sébastien Lofek, Jérémie Dion, Benjamin Chaigne, …, Loïc Guillevin, Véronique Witko-Sarsat, Nadine Varin-Blank, Benjamin Terrier, Luc Mouthon
Rheumatology  ·  07 Oct 2020  ·  doi:10.1093/rheumatology/keaa432
The adaptor protein APS modulates BCR signalling in mature B cells
The adaptor protein APS modulates BCR signalling in mature B cells
Elisabetta Dondi, Jean-Baptiste Sibarita, Nadine Varin-Blank, Laura Velazquez
Cellular Signalling  ·  01 Sep 2020  ·  doi:10.1016/j.cellsig.2020.109673
test9
Stabilization of β-catenin upon B-cell receptor signaling promotes NF-kB target genes transcription in mantle cell lymphoma
Stabilization of β-catenin upon B-cell receptor signaling promotes NF-kB target genes transcription in mantle cell lymphoma
Gregory Lazarian, Chloe Friedrich, Anne Quinquenel, Julie Tran, Souhail Ouriemmi, …, John G. Gribben, Florence Cymbalista, Nadine Varin-Blank, Laura Gardano, Fanny Baran-Marszak
Oncogene  ·  07 Feb 2020  ·  doi:10.1038/s41388-020-1183-x
test10