Characterization of endosomal trafficking and BCR activation in leukemic B lymphocytes
l. saveanu
Characterization of endosomal trafficking and BCR activation in leukemic B lymphocytes. PI (2024-2030, grant USPN), collaboration with L. Saveanu (CRI)
The molecular mechanisms underlying BCR signaling, particularly endocytosis and endosomal trafficking in B-cells from CLL or MCL, remain largely unknown. The main objective of this project is to characterize vesicular endosomes in three areas: 1) trafficking and recycling, 2) BCR signaling, and 3) antigen presentation from B cell lines, healthy donnor B cells, and ex vivo B-CLL cells. The project is conducted in collaboration with teams from Labex Infibrex (Loredana Saveanu and Ulrich Blank at the Center for Inflammation Research, Bichat Faculty of Medicine, INSERM U1149).
This project is funded by
