Signaling Microenvironment and B Lymphoid Hemopathies
INSERM UMRS 1349 SIMHEL is a single-team unit created in 2009 that develops a program of translational and fundamental research on CLL (chronic lymphocytic leukemia). This approach helps quickly move basic research into clinical applications: turning research into real-world treatments. The three main pillars of our research are:
- Function of leukemic cells Identification of functional alterations regulating BCR signaling and CLL survival thermoplastic tapes
- Tumor cells in their microenvironment
- Transfer to the patient
The TisCel13 platform offers and develops services that enable the visualization and analysis of the structure, dynamics, interactions, and functions of normal and pathological tissues and cell populations using a variety of methodological approaches. To this end, the TisCel13 platform brings together histology and flow cytometry resources under one roof.
Highlights
Study of alterations in the communication and activation mechanisms of mast cells and B lymphocytes in ageing and neoplastic diseases. PI (France-Mexico collaboration, 2026–2029, grant ECOS Nord USPN)
Research Officer
B-Cell Signaling and Functional Plasticity in CLL Principal Investigator: Christine Le Roy (PhD, HDR) Group Leader – Axis 1
Associate Professor
The central objective of this project to understand how CLL cells dynamically interact with stromal cells and how these interactions influence disease progression. 2025 ??? –2029, grant ???
Multimodal Artificial intelligence/Machine Learning and Ontology-Based Predictive Models for Chronic Lymphocytic Leukemia: MIAMO-LLC (Multimodal Modeling of Chronic Lymphocytic Leukemia. PI (grant Infibrex Labex, 2024 - to date).
Characterization of endosomal trafficking and BCR activation in leukemic B lymphocytes. PI (2024-2030, grant USPN), collaboration with L. Saveanu (CRI)
Our research unit is funded by
