Science
Translational and basic research on CLL focuses on three main areas: 1) better defining genetic and functional alterations, particularly with the aim of improving patient stratification and understanding tumor progression; 2) determining the influence of the tumor microenvironment on tumor progression; 3) translational and machine learning models for integrating fundamental and clinical-biological data into preclinical research.
LLC Drivers, Functional Plasticity and Regulatory Mechanisms => Stratification markers
Permissive stromal environment, Tolerogenic environment, Molecular interactions => Identification of alternative therapeutic targets
Established a clinical and biological database => Preclinical studies
Learn more about our research. Research projects
Ongoing projects
Study of alterations in the communication and activation mechanisms of mast cells and B lymphocytes in ageing and neoplastic diseases. PI (France-Mexico collaboration, 2026–2029, grant ECOS Nord USPN)
Research Officer
B-Cell Signaling and Functional Plasticity in CLL Principal Investigator: Christine Le Roy (PhD, HDR) Group Leader – Axis 1
Associate Professor
The central objective of this project to understand how CLL cells dynamically interact with stromal cells and how these interactions influence disease progression. 2025 ??? –2029, grant ???
Multimodal Artificial intelligence/Machine Learning and Ontology-Based Predictive Models for Chronic Lymphocytic Leukemia: MIAMO-LLC (Multimodal Modeling of Chronic Lymphocytic Leukemia. PI (grant Infibrex Labex, 2024 - to date).
Characterization of endosomal trafficking and BCR activation in leukemic B lymphocytes. PI (2024-2030, grant USPN), collaboration with L. Saveanu (CRI)